Hi José,
I think you are not being clear enough, but I think I get it now.
What you want to do is to prescribe a variable discharge (flowrate) for Telemac2d and variable solids discharge (sediment entering), both time-varying, am I right? If so, the answer is yes, it is possible. Use one liquid boundary file for t2d and another one for Sisyphe.
As I said previously, you should take a look at the manual; there are some considerations about what you want to do.
I hope it helps, if not, would be helpful a deeper description about the case you are running!
Cheers,
José