Hello,
I am not sure what is exactly you are asking, but if I understood correctly you are trying to start a telemac2d computation from within a python script. I am sure there is a more 'pythonic' way to do this, but what I do is construct the command as a string and then call it with subprocess. Here is an non-working example to get the idea.
import subprocess
t2d_sis = r'telemac2d.py -c gfmsmpi_i7 --ncsize=4 t2d_sis.cas'
subprocess.check_call(t2d_sis, shell=True)
Of course paths etc, need to be sorted out first.
Regards,
Costas