Hello,
Flood events have been done with Telemac-2D on 2000 square kms domains, during 2 months, so it would be worth looking also at the numerical options, maybe some optimisation is possible.
To know how efficient is your computer you can test in version 6.2 the Malpasset case. On a desktop HP Z600 Linux 64 bits with 8 processors, it takes 4 s (speed-up 5 to 6). Other deskstop machines now take 3 s, and HP Z620 has 16 cores, it should be even faster.
With very large domains like yours, the speed-up due to parallelism should be very good even with a large number of processors.
With best regards,
Jean-Michel Hervouet